{4-[2-(4-Bromo-benzyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenylamino}-acetic acid methyl ester → (4-{4-(2,4-Dichloro-phenyl)-2-[4'-(4-methyl-pentyl)-biphenyl-4-ylmethyl]-imidazol-1-yl}-phenylamino)-acetic acid methyl ester

Participants

Role	Name	HCID	Charge
Reactant	{4-[2-(4-Bromo-benzyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenylamino}-acetic acid methyl ester	HCID 68583535	—
Reactant	4-(4-Methylpentyl)phenyl boronic acid	HCID 68583667	—
Product	(4-{4-(2,4-Dichloro-phenyl)-2-[4'-(4-methyl-pentyl)-biphenyl-4-ylmethyl]-imidazol-1-yl}-phenylamino)-acetic acid methyl ester	HCID 68583189	—

Reaction Steps

{4-[2-(4-Bromo-benzyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenylamino}-acetic acid methyl ester (500 mg, 0.91 mmol) was coupled with 4-(4-methylpentyl)phenyl boronic acid according to general procedure G to give (4-{4-(2,4-dichloro-phenyl)-2-[4′-(4-methyl-pentyl)-biphenyl-4-ylmethyl]-imidazol-1-yl}-phenylamino)-acetic acid methyl ester.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07723369B2
Source dataset	uspto-grants-2010_05
ORD ID	ord-1095119d97684125bc590303e6e9325e
Source note	uspto-grants-2010_05