Tetrabutylammonium Fluoride → HCID 59305431, compound

HRID 2240764Notes

Reaction equation

HRID 2240764 reaction equation
[CH:1]1([CH2:7][O:8][C:9]2[N:14]=[N:13][C:12]([C:15]3[CH:56]=[CH:55][C:18]([CH2:19][C:20]4[N:21]([C:33]5[CH:34]=[C:35]([N:39]6[S:43](=[O:45])(=[O:44])[N:42](COCC[Si](C)(C)C)[C:41](=[O:54])[CH2:40]6)[CH:36]=[CH:37][CH:38]=5)[CH:22]=[C:23]([C:25]5[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:26]=5[Cl:32])[N:24]=4)=[CH:17][CH:16]=3)=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>>[CH:1]1([CH2:7][O:8][C:9]2[N:14]=[N:13][C:12]([C:15]3[CH:56]=[CH:55][C:18]([CH2:19][C:20]4[N:21]([C:33]5[CH:34]=[C:35]([N:39]6[S:43](=[O:44])(=[O:45])[NH:42][C:41](=[O:54])[CH2:40]6)[CH:36]=[CH:37][CH:38]=5)[CH:22]=[C:23]([C:25]5[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:26]=5[Cl:32])[N:24]=4)=[CH:17][CH:16]=3)=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 68584387HCID 68584387, compound

Product 1

HCID 59305431HCID 59305431, compound

Procedure

5-{3-[2-[4-(6-Cyclohexylmethoxy-pyridazin-3-yl)-benzyl]-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenyl}-1,1-dioxo-2-(2-trimethylsilanyl-ethoxymethyl)-[1,2,5]thiadiazolidin-3-one (17 mg, 0.02 mmol) was treated as described in general procedure W using tetrabutylammonium fluoride (26 mg, 0.1 mmol) to give 5-{3-[2-[4-(6-cyclohexylmethoxy-pyridazin-3-yl)-benzyl]-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenyl}-1,2,5-thiadiazolidine-3-one-1,1-dioxide.

Sources & evidence

ORD record
ord-8192189f7180449e959208e13a211c5a
Source dataset
uspto-grants-2010_05
Patent number
US07723369B2

Reaction notes

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