反应详情

To the appropriate phenols (50 μmol, 2 eq.) and K2CO3 (10.5 mg, 75 μmol) a solution of 2-bromo-1-(3,5,5-trimethyl-4,5,6,7-tetrahydro-benzo[c]thiophen-1-yl)-ethanone (7.5 mg, 25 μmol) in acetone (0.7 mL) is added. The suspension is stirred at rt for 18 h before it is filtered. The solvent of the filtrate is evaporated and the crude product is purified by prep. HPLC (Symmetry C18 5 μm, 19×50 mm, 20-95% acetonitrile in water containing 0.5% formic acid) to give the desired 2-phenoxy-1-(3,5,5-trimethyl-4,5,6,7-tetrahydro-benzo[c]thiophen-1-yl)-ethanone.

1. filtrationis filtered
2. customThe solvent of the filtrate is evaporated
3. customthe crude product is purified by prep