反应详情

温度

165 °C

A mixture of 2,2-dimethyl-3-phenyl-cyclopropanecarbonitrile (cis/trans mixture, 3.2 g, 18.7 mmol) and freshly ground KOH (3.143 g, 56.1 mmol) in ethylene glycol was heated at 165° C. for 28 hours. The reaction mixture was then cooled and poured into a mixture of water and brine (300 mL). The resulting mixture was extracted 3 times with ethyl ether, the combined organic extracts were dried over Na2SO4, filtered and evaporated under reduced pressure to give 3.36 g (95% yield) of trans-2,2-dimethyl-3-phenyl-cyclopropanecarboxylic acid.

1. temperatureThe reaction mixture was then cooled
2. extractionThe resulting mixture was extracted 3 times with ethyl ether
3. dry with materialthe combined organic extracts were dried over Na2SO4
4. filtrationfiltered
5. customevaporated under reduced pressure