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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2240866Generated: October 26, 2026

Cyclohexylamine → N2-[4-Cyano-3-(trifluoromethyl)phenyl]-N1-cyclohexyl-N2-(2,2,2-trifluoroethyl)glycinamide

https://huagongshe.com/reaction/2240866

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyclohexylamineHCID 7965—
ReactantN-[4-cyano-3-(trifluoromethyl)phenyl]-N-(2,2,2-trifluoroethyl)glycineHCID 57633731—
ProductN2-[4-Cyano-3-(trifluoromethyl)phenyl]-N1-cyclohexyl-N2-(2,2,2-trifluoroethyl)glycinamideHCID 11774153—

Reaction Steps

Synthesized as described in example 3 using N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(2,2,2-trifluoroethyl)glycine and cyclohexylamine: 1H NMR (400 MHz, CDCl3) δ 7.68 (d, J=8.8 Hz, 1H), 7.03 (d, J=2.6 Hz, 1H), 6.92 (dd, J=8.8, 2.7 Hz, 1H), 5.81 (d, J=8.0 Hz, 1H), 4.12 (s, 2H), 4.10 (q, J=8.6 Hz, 2H), 3.80 (m, 1H), 1.83 (m, 2H), 1.63 (m, 3H), 1.32 (m, 2H), 1.08 (m, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07723385B2
Source datasetuspto-grants-2010_05
ORD IDord-bb675c0306024c8a9e9b0967d5d53861
Source noteuspto-grants-2010_05