tert-Butyl 2-bromopropanoate → HCID 11336595, compound

HRID 2240902Notes

Reaction equation

HRID 2240902 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([NH:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].Br[CH:16]([CH3:24])[C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18]>>[Cl:1][C:2]1[CH:9]=[C:8]([N:10]([CH2:11][CH:12]2[CH2:14][CH2:13]2)[C@H:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH3:24])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Participants

3

Reactant 2

HCID 545327tert-Butyl 2-bromopropanoateHCID 43560354HCID 43560354, compound

Product 1

HCID 11336595HCID 11336595, compound

Procedure

Synthesized in a manner similar to example 1B using 2-chloro-4-[(cyclopropylmethyl)amino]benzonitrile and 1,1-dimethylethyl 2-bromopropanoate: MS (ES) m/z 335 (M+1).

Workup

  1. customSynthesized in a manner similar to example 1B

Sources & evidence

ORD record
ord-fc8382f314bb495da1b63e4d645bbf12
Source dataset
uspto-grants-2010_05
Patent number
US07723385B2

Reaction notes

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