Nanofin → HCID 59305341, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(3-bromo-4-fluorophenyl)-2-[4-(difluoromethoxy)phenyl-]ethane-1,2-dione (2.1 g, 5.63 mmol), 2,6-dimethylpiperidine (10 mL), and ethynylcyclopropane (0.74 g, 11.27 mmol) was degassed with argon for 5 minutes. The reaction mixture was treated with tetrakis(triphenylphosphine) palladium (0) (327 mg, 0.28 mmol), stirred at 80° C. for 5 h, cooled to room temperature, poured into water and extracted with EtOAc. The extracts were combined, dried over MgSO4, and concentrated in vacuo. Purification of the resultant residue by ICSO (hexane/EtOAc 5/1) gave 1-[3-(cyclopropylethynyl)-4-fluorophenyl]-2-[4-(difluoromethoxy)phenyl]ethane-1,2-dione as a yellow oil solid (1.37 g);

Provenance & Evidence