Ethanol → HCID 16112965, compound

Participants

Reaction Conditions

Reaction Steps

1-(4-(difluoromethoxy)phenyl)-2-(3-hydroxyphenyl)ethane-1,2-dione (0.11 g, 0.38 mmol) was dissolved in ethanol (5 mL). Methylguanidine hydrochloride (0.052 g, 0.47 mmol) was added followed by sodium carbonate (0.050 g, 0.47 mmol). The mixture was stirred at 85° C. overnight 15 hours. The solvent was removed and the material is absorbed onto celite. Purification by flash chromatography afforded 2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-hydroxyphenyl)-1-methyl-1H-imidazol-5(4H)-one (0.085 g, 64%).

Provenance & Evidence