HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-Fluoro-5-((triisopropylsilyl)ethynyl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Phenol, 5-bromo-2-fluoro- | HCID 183421 | — |
| Reactant | (Triisopropylsilyl)acetylene | HCID 2734682 | — |
| Catalyst | Copper iodide | HCID 83717 | — |
| Catalyst | HCID 178479804 | HCID 178479804 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Fluoro-5-((triisopropylsilyl)ethynyl)phenol | HCID 59305361 | — |
Reaction Steps
A solution of Ethynyl-triisopropyl-silane (1.13 g, 6.20 mmol), 5-bromo-2-fluorophenol (0.955 g, 4.98 mmol), bis(triphenylphosphino)palladium(II) chloride (0.105 g, 0.15 mmol), copper iodide (0.039 g, 0.205 mmol) and triethylamine (2.9 g, 28.7 mmol) in DMF (4.0 mL) is irradiated in the CEM explorer at 80° C. for 30 min. The solvent is removed and the product purified by Flash Chromatography to yield 2-fluoro-5-((triisopropylsilyl)ethynyl)phenol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723368B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-6b105eb3a7664ab69b70e35d3c227fb1 |
| Source note | uspto-grants-2010_05 |