2-Iodotoluene → 1-{[4-(Difluoromethoxy)phenyl]ethynyl}-2-methylbenzene

HRID 2240945Notes

Reaction equation

HRID 2240945 reaction equation
I[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:8].[F:9][CH:10]([F:20])[O:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]#[CH:19])=[CH:14][CH:13]=1>>[F:9][CH:10]([F:20])[O:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]#[C:19][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[CH3:8])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 51282-IodotolueneHCID 27784971-(Difluoromethoxy)-4-ethynylbenzene

Product 1

HCID 593053541-{[4-(Difluoromethoxy)phenyl]ethynyl}-2-methylbenzene

Procedure

The title compound was prepared in substantially the same manner as described in Example 12, step 3 starting from 1-Iodo-2-methyl-benzene (0.15 g, 0.69 mmol), and 1-Difluoromethoxy-4-ethynyl-benzene (0.116 g, 0.69 mmol), and was obtained as a light brown oil, (0.141 g, 79%), identified by NMR and mass spectral analyses. MS (EI+): 258 (M+).

Workup

  1. customwas obtained as a light brown oil, (0.141 g, 79%),

Sources & evidence

ORD record
ord-9178ee06b9b14365aad21c5d1251d2fe
Source dataset
uspto-grants-2010_05
Patent number
US07723368B2

Reaction notes

Loading…