Acetic Acid → HCID 67539132, compound

Participants

Reaction Steps

A mixture 2-amino-5-(3-amino-phenyl)-5-(4-difluoromethoxy-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one (150 mg, 0.43 mmol), propionaldehyde (25 mg, 0.43 mmol), sodium triacetoxyborohydride (184 mg, 0.87 mmol), and acetic acid (0.87 mmol) in dichloroethane (4.3 mL) was stirred at room temperature overnight. The reaction was diluted with methylene chloride and washed with sodium carbonate. The organic layer was concentrated and purified by reverse-phase HPLC followed by treatment with hydrochloric acid to provide the title compound (122 mg, 73%), characterized by NMR and mass spectral analyses. MS (ES+) m/e 389 (M+H)+.

Provenance & Evidence