Dimethyl Sulfoxide → HCID 67538041, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(2-cyclopropyl-1-fluorovinyl)-3-{[4-(difluoromethoxy)phenyl]ethynyl}benzene (0.1 g, 0.3 mmol) and DMSO (1 mL) was degassed with argon for 5 minutes. Then, bis(acetonitrile)dichloropalladium (II) (7.8 mg, 0.03 mmol) was added and the mixture was stirred at 145° C. for 8 hours. Then, the mixture was poured into water and extracted with EtOAc. The organic extracts were dried over MgSO4. Evaporation and purification by ICSO (hexane/EtOAc 4/1) gave 1-[3-(2-cyclopropyl-1-fluorovinyl)phenyl]-2-[4-(difluoromethoxy)phenyl]ethane-1,2-dione 1:1 Z/E isomers (78 mg); MS m/e (M)+ 360.

Provenance & Evidence