HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 57577469, compound → HCID 67538393, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 57577469 | HCID 57577469 | — |
| Reactant | HCID 86627697 | HCID 86627697 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67538393 | HCID 67538393 | — |
Reaction Steps
This compound was made in a similar manner to Example 89 Step 4 using 1-(3,3-difluoropropoxy)-3-ethynylbenzene (650 mg, 3.13 mmol) from the previous step, 1-(difluoromethoxy)-4-iodo-2-methylbenzene (818 mg, 2.88 mmol), TEA (1.45 g, 2.0 mL, 14.5 mmol), PdCl2(PPh3)2 (101 mg, 0.144 mmol), and CuI (16.4 mg, 0.0864 mmol), and DMF (4.4 mL) to provide the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723368B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-5c0ef3d4bbd64421b54da4d32f796850 |
| Source note | uspto-grants-2010_05 |