Potassium Carbonate → HCID 86627700, compound

Participants

Reaction Steps

To a solution of the crude ((3-(3,3-difluoropropoxy)-4-fluorophenyl)ethynyl)trimethylsilane (2.0 g) from the previous step in MeOH (17.5 mL) was added K2CO3 (9.65 g, 69.8 mmol) at room temperature. The reaction mixture was stirred for 1.5 h after which the mixture was filtered. The filter cake was washed with MeOH and the combined filtrate was concentrated over 10 g Celite. Flash chromatography (SiO2, % EtOAc 99% Hexanes to 5:95 EtOAc:Hexanes) provided 700 mg, 76%, of the title compound as a light yellow oil.

Provenance & Evidence