(Diethylamino)sulfur trifluoride → HCID 67537887, compound

Participants

Reaction Conditions

Reaction Steps

1-(4-(Difluoromethoxy)phenyl)-2-(3-(3-hydroxyprop-1-ynyl)phenyl)ethane-1,2-dione (0.298 g, 0.90 mmol) is dissolved in CH2Cl2 (3.0 mL) and cooled to −78° C. DAST (0.160 g, 0.99 mmol) is added and the solution is slowly warmed to RT. After 1 h at RT a saturated solution of NaHCO3 is added and the mixture extracted with CH2Cl2. The CH2Cl2 is washed with H2O and brine. The solution is dried (MgSO4) and the material purified by flash chromatography to yield 1-(4-(difluoromethoxy)phenyl)-2-(3-(3-fluoroprop-1-ynyl)phenyl)ethane-1,2-dione (0.232, 77%).

Provenance & Evidence