3-Butyn-1-OL → HCID 67537006, compound

HRID 2241016Notes

Reaction equation

HRID 2241016 reaction equation
[NH2:1][C:2]1[N:6]([CH3:7])[C:5](=[O:8])[C:4]([C:19]2[CH:24]=[CH:23][C:22]([O:25][CH:26]([F:28])[F:27])=[CH:21][CH:20]=2)([C:9]2[CH:14]=[CH:13][CH:12]=[C:11](C#CCF)[CH:10]=2)[N:3]=1.[F:29]C(F)OC1C=CC(C(=O)C(C2C=CC=C(C#CCO)C=2)=O)=CC=1.[CH2:53](O)[CH2:54][C:55]#[CH:56]>>[NH2:1][C:2]1[N:6]([CH3:7])[C:5](=[O:8])[C:4]([C:19]2[CH:20]=[CH:21][C:22]([O:25][CH:26]([F:28])[F:27])=[CH:23][CH:24]=2)([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:56]#[C:55][CH2:54][CH2:53][F:29])[CH:10]=2)[N:3]=1

Participants

4

Reactant 3

HCID 135663-Butyn-1-OLHCID 16112964HCID 16112964, compoundHCID 67539293HCID 67539293, compound

Product 1

HCID 67537006HCID 67537006, compound

Procedure

This material was synthesized in a fashion similar to 2-amino-5-[4-(difluoromethoxy)phenyl]-5-[3-(3-fluoroprop-1-yn-1-yl)phenyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one by coupling 1-(4-(difluoromethoxy)phenyl)-2-(3-(3-hydroxyprop-1-ynyl)phenyl)ethane-1,2-dione with but-3-yn-1-ol in step 1.

Sources & evidence

ORD record
ord-5b5be51e97de4c6c9629f612f7205f60
Source dataset
uspto-grants-2010_05
Patent number
US07723368B2

Reaction notes

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