Propargyl alcohol → HCID 67538654, compound

HRID 2241017Notes

Reaction equation

HRID 2241017 reaction equation
[NH2:1][C:2]1[N:6]([CH3:7])[C:5](=[O:8])[C:4]([C:19]2[CH:24]=[CH:23][C:22]([O:25][CH:26]([F:28])[F:27])=[CH:21][CH:20]=2)([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]#[C:16][CH2:17][F:18])[CH:10]=2)[N:3]=1.BrC1C=C(C(=O)C(C2C=CC(OC(F)F)=CC=2)=O)C=CC=1[F:36].C(O)C#C>>[NH2:1][C:2]1[N:6]([CH3:7])[C:5](=[O:8])[C:4]([C:19]2[CH:20]=[CH:21][C:22]([O:25][CH:26]([F:28])[F:27])=[CH:23][CH:24]=2)([C:9]2[CH:14]=[CH:13][C:12]([F:36])=[C:11]([C:15]#[C:16][CH2:17][F:18])[CH:10]=2)[N:3]=1

Participants

4

Reactant 3

HCID 7859Propargyl alcoholHCID 16112964HCID 16112964, compoundHCID 59790308HCID 59790308, compound

Product 1

HCID 67538654HCID 67538654, compound

Procedure

This material was synthesized in a fashion similar to 2-amino-5-[4-(difluoromethoxy)phenyl]-5-[3-(3-fluoroprop-1-yn-1-yl)phenyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one by coupling 1-(3-bromo-4-fluorophenyl)-2-(4-(difluoromethoxy)phenyl)ethane-1,2-dione with prop-2-yn-1-ol in step 1.

Sources & evidence

ORD record
ord-f24e7d457d844470a2c4f7c6b7f035ba
Source dataset
uspto-grants-2010_05
Patent number
US07723368B2

Reaction notes

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