Trifluoroacetic acid → HCID 11992569, compound

Participants

Reaction Steps

A mixture of 26 (˜700 mg, a mixture obtained from the above) and CH2Cl2 (8 mL) was treated with CF3CO2H (2 mL) at RT. The reaction mixture stirred at RT under N2 for 1.5 h and then concentrated under reduced pressure to afford the crude product. The crude material was purified by column chromatography to afford 165 mg of the desired product 27 as a white solid. A portion (350 mg) of the starting triflate 25 was also recovered. Data for 27: 1H NMR (400 MHz, CD3OD): δ 7.64 (d, J=16.0 Hz, 1H), 7.52 (d, J=8.0 Hz, 2H), 7.21 (d, J=8.0 Hz, 2H), 7.18 (d, J=5.6 Hz, 1H), 7.16 (d, J=5.6 Hz, 1H), 7.00 (t, J=8.8 Hz, 2H), 6.44 (d, J=16.00 Hz, 1H), 1.99 (s, 2H), 1.97 (s, 2H), 1.31 (s, 2H), 0.93 (s, 12H). LCMS (APCI): m/z 391 (M−H)−.

Provenance & Evidence