Potassium Carbonate → HCID 86621473, compound

Participants

Reaction Conditions

Reaction Steps

Bromoethylacetate (187 mg, 1.12 mmol), compound 41 (150 mg, 0.449 mmol), and K2CO3 (185 mg, 1.34 mmol) were combined with dry acetone (5 mL) in a sealed microwave vessel. The mixture was heated at 100° C. for 20 minutes in a Personal Chemistry Emrys Optimizer microwave. The reaction was allowed to cool to room temperature and the solids filtered. The solids were rinsed twice with acetone and the solvent was removed in vacuuo to give 187 mg (99%) of compound 42. The crude material was used without additional purification. 1H NMR (400 MHz, CDCl3): δ 0.88 (s, 6H), 0.91 (s, 6H), 1.20-1.25 (m, 5H), 1.75 (s, 2H), 1.90 (s, 2H), 2.23 (s, 3H), 4.22 (m, 3H), 4.46 (s, 2H), 6.73 (d, J=8.3 Hz, 1H), 6.75-7.05 (m, 2H), 7.09-7.46 (m, 5H).

Provenance & Evidence