O-ethyl chloromethanethioate → HCID 6004099, compound

HRID 2241100Notes

Reaction equation

HRID 2241100 reaction equation
[C:1]([C:3]1[C:11]2[CH2:10][CH2:9][NH:8][CH2:7][C:6]=2[S:5][C:4]=1[NH:12][C:13](=[O:22])[CH:14]=[CH:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)#[N:2].C(C1C2CCNCC=2SC=1N[C:35](=[O:44])[CH:36]=CC1C=NC=CC=1)#N.ClC(OCC)=S>>[C:35]([N:8]1[CH2:9][CH2:10][C:11]2[C:3]([C:1]#[N:2])=[C:4]([NH:12][C:13](=[O:22])/[CH:14]=[CH:15]/[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[S:5][C:6]=2[CH2:7]1)(=[O:44])[CH3:36]

Participants

4

Reactant 3

HCID 5325481O-ethyl chloromethanethioateHCID 68607711HCID 68607711, compound2×HCID 68608204HCID 68608204, compound2×

Product 1

HCID 6004099HCID 6004099, compound

Procedure

The following compounds 35 and 36 can be prepared according to the general procedure F described below starting from N-(3-cyano-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl)-3-phenyl-acrylamide (compound B1) or N-(3-cyano-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl)-3-(pyridin-3-yl)-acrylamide (compound B2) and ethyl chlorothioformate.

Sources & evidence

ORD record
ord-9afeca30a1004200ab3235656a071455
Source dataset
uspto-grants-2010_05
Patent number
US07723523B2

Reaction notes

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