Isocyanate → HCID 59306303, compound

HRID 2241101Notes

Reaction equation

HRID 2241101 reaction equation
C([C:3]1C2CCNC[C:6]=2[S:5][C:4]=1NC(=O)C=CC1C=CC=CC=1)#N.[C:23]([C:25]1[C:33]2[CH2:32][CH2:31][NH:30][CH2:29][C:28]=2[S:27][C:26]=1[NH:34][C:35](=[O:44])[CH:36]=[CH:37][C:38]1[CH:39]=[N:40][CH:41]=[CH:42][CH:43]=1)#[N:24].[N-]=C=[O:47]>>[CH2:4]([S:5][C:6]([N:30]1[CH2:31][CH2:32][C:33]2[C:25]([C:23]#[N:24])=[C:26]([NH:34][C:35](=[O:44])/[CH:36]=[CH:37]/[C:38]3[CH:39]=[N:40][CH:41]=[CH:42][CH:43]=3)[S:27][C:28]=2[CH2:29]1)=[O:47])[CH3:3]

Participants

4

Reactant 3

HCID 105034IsocyanateHCID 68607711HCID 68607711, compound2×HCID 68608204HCID 68608204, compound2×

Product 1

HCID 59306303HCID 59306303, compound

Procedure

The following compounds 37 and 38 can be prepared according to the general procedure G described below starting from N-(3-cyano-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl)-3-phenyl-acrylamide (compound B1) or N-(3-cyano-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl)-3-(pyridin-3-yl)-acrylamide (compound B2) and the appropriate isocyanate or amine/carbonyldiimidazole.

Sources & evidence

ORD record
ord-b914774f779f4bf48a435db7e80fa5aa
Source dataset
uspto-grants-2010_05
Patent number
US07723523B2

Reaction notes

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