5-(Nitrooxy)pentanoic acid pentafluorophenyl ester → HCID 178441676, compound

Participants

Reaction Steps

Using the same procedure described in Example 1 but starting from 2-Butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol (Losartan) (0.93 g, 2.19 mmol) and 5-(nitrooxy)pentanoic acid pentafluorophenyl ester (0.72 g, 2.19 mmol) TEA (0.30 ml, 2.19 mmol), DMAP (0.27 g, 2.19 mmol) after purification with Flash chromatography of the residue (CH2Cl2/MeOH 98:2) the title compound (0.72 g, 60%) was obtained as a white foam.

Provenance & Evidence