Pentafluorophenol → 4-Chlorobutyl pentafluorophenyl carbonate

HRID 2241114Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2241114
[F:1][C:2]1[C:7]([OH:8])=[C:6]([F:9])[C:5]([F:10])=[C:4]([F:11])[C:3]=1[F:12].Cl[C:14]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][Cl:21])=[O:15]>C(Cl)(Cl)Cl.OS([O-])(=O)=O.[K+]>[C:14](=[O:15])([O:8][C:7]1[C:2]([F:1])=[C:3]([F:12])[C:4]([F:11])=[C:5]([F:10])[C:6]=1[F:9])[O:16][CH2:17][CH2:18][CH2:19][CH2:20][Cl:21]

Komponenten

5

Edukt 2

HCID 13041PentafluorophenolHCID 27333284-Chlorobutyl carbonochloridate

Produkt 1

HCID 860918154-Chlorobutyl pentafluorophenyl carbonateAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6212ChloroformLösungsmittel2×HCID 516920Potassium bisulfateLösungsmittel

Versuchsvorschrift

To a solution of pentafluorophenol (1 g, 5.43 mmol) and TEA (0.91 ml, 6.52 mmol) in CHCl3 (8 ml), cooled to 0° C. and under nitrogen, a solution of 4-chlorobutyl chloroformate (0.76 ml, 5.43 mmol) in CHCl3 (1 ml) was dropped into. The mixture was allowed to warm to room temperature and stirred for 480 minutes. Then it was diluted with aqueous KHSO4 (2%), the two phases were separated and the organic phase was dried and evaporated yielding 4-chlorobutyl pentafluorophenyl carbonate (1.69 g, 98%) as a colorless oil that was used without further purification.

Aufarbeitung

  1. customthe two phases were separated
  2. customthe organic phase was dried
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-f54ee8cbad4242d2a89970192df5aac4
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07723529B2

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