反应详情

To a solution of pentafluorophenol (1 g, 5.43 mmol) and TEA (0.91 ml, 6.52 mmol) in CHCl3 (8 ml), cooled to 0° C. and under nitrogen, a solution of 4-chlorobutyl chloroformate (0.76 ml, 5.43 mmol) in CHCl3 (1 ml) was dropped into. The mixture was allowed to warm to room temperature and stirred for 480 minutes. Then it was diluted with aqueous KHSO4 (2%), the two phases were separated and the organic phase was dried and evaporated yielding 4-chlorobutyl pentafluorophenyl carbonate (1.69 g, 98%) as a colorless oil that was used without further purification.

1. customthe two phases were separated
2. customthe organic phase was dried
3. customevaporated