Sodium Iodide → 4-Iodobutyl pentafluorophenyl carbonate

HRID 2241115노트

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HRID 2241115 반응식
[C:1](=[O:20])([O:8][C:9]1[C:14]([F:15])=[C:13]([F:16])[C:12]([F:17])=[C:11]([F:18])[C:10]=1[F:19])[O:2][CH2:3][CH2:4][CH2:5][CH2:6]Cl.[Na+].[I-:22]>CC#N>[C:1](=[O:20])([O:8][C:9]1[C:14]([F:15])=[C:13]([F:16])[C:12]([F:17])=[C:11]([F:18])[C:10]=1[F:19])[O:2][CH2:3][CH2:4][CH2:5][CH2:6][I:22]

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 860918154-Chlorobutyl pentafluorophenyl carbonate

생성물 1

HCID 860918174-Iodobutyl pentafluorophenyl carbonate수율 90%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 4-chlorobutyl pentafluorophenyl carbonate (1.69 g, 5.3 mmol) and NaI (7.99 g, 53.3 mmol) in CH3CN (20 ml) was refluxed under nitrogen for 960 minutes. Then the solvent was evaporated and the residue taken up with CH2Cl2 and washed with water (2×50 ml). The organic phase was then dried and evaporated yielding 4-iodobutyl pentafluorophenyl carbonate (1.95 g, 90%) as a yellow oil that was used without further purification.

후처리

  1. temperaturewas refluxed under nitrogen for 960 minutes
  2. customThen the solvent was evaporated
  3. washwashed with water (2×50 ml)
  4. customThe organic phase was then dried
  5. customevaporated

출처 및 근거

ORD 기록
ord-a2c55dd09ee04376be90600e624b8b28
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07723529B2

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