反应详情

温度

90 °C

Ethyl 3-hydroxyiminomethyl-2,4,5-trifluorobenzoate (5.5 g, 24.0 mmol) was dissolved in trichloroacetonitrile (25 g), and the solution was stirred at 90° C. for 16 hours. The reaction mixture was left to cool, and the solid matter that precipitated was separated through filtration. The filtrate was concentrated under reduced pressure. The residue was subjected to silica gel chromatography (eluent; n-hexane ethyl acetate=10:1), to thereby yield the title compound as a colorless oily substance (3.35 g, 61%).

1. waitThe reaction mixture was left
2. temperatureto cool
3. customthe solid matter that precipitated
4. customwas separated through filtration
5. concentrationThe filtrate was concentrated under reduced pressure