Benzenesulfonyl chloride → HCID 41466018, compound

HRID 2241127Notes

Reaction equation

HRID 2241127 reaction equation
[CH2:1]([O:3][C:4](=[O:21])[C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:20])[C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([NH2:19])[CH:14]=2)=[CH:7][CH:6]=1)[CH3:2].[C:22]1([S:28](Cl)(=[O:30])=[O:29])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>N1C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:21])[C:5]1[CH:6]=[CH:7][C:8]([NH:11][C:12](=[O:20])[C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([NH:19][S:28]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)(=[O:30])=[O:29])[CH:14]=2)=[CH:9][CH:10]=1)[CH3:2]

Participants

4

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 24271945Ethyl 4-(3-aminobenzamido)benzoate

Product 1

HCID 41466018HCID 41466018, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent2×

Procedure

A solution of 4-(3-amino-benzoylamino)-benzoic acid ethyl ester (50.0 mg, 0.18 mmol) in pyridine (0.40 ml) was treated with a solution of benzensulfonyl chloride (31.0 mg, 0.18 mmol) in pyridine (0.10 ml). The mixture was stirred at room temperature overnight. The solvent was evaporated, yielding crude 4-(3-benzenesulfonylamino-benzoylamino)-benzoic acid ethyl ester, MS (ISP): m/e=425.1 (M+H+), which was used as such in the next step.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-be704f2d155841a38e3d353bafd9e9f1
Source dataset
uspto-grants-2010_05
Patent number
US07723538B2

Reaction notes

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