2-Methoxybenzenesulfonyl Chloride → HCID 68406939, compound

HRID 2241131Notes

Reaction equation

HRID 2241131 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([NH:12][C:13]1[CH:14]=[C:15]([CH:28]=[CH:29][CH:30]=1)[C:16]([NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=1)=[O:17])(=[O:11])=[O:10].CO[C:33]1C=CC=C[C:34]=1S(Cl)(=O)=O>>[CH2:33]([O:24][C:23](=[O:25])[C:22]1[CH:21]=[CH:20][C:19]([NH:18][C:16](=[O:17])[C:15]2[CH:28]=[CH:29][CH:30]=[C:13]([NH:12][S:9]([C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=3[O:2][CH3:1])(=[O:11])=[O:10])[CH:14]=2)=[CH:27][CH:26]=1)[CH3:34]

Participants

3

Reactant 2

HCID 37458512-Methoxybenzenesulfonyl ChlorideHCID 11979265HCID 11979265, compound

Product 1

HCID 68406939HCID 68406939, compound

Procedure

4-[3-(2-Methoxy-benzenesulfonylamino)-benzoylamino]-benzoic acid, MS (ISP): m/e=425.1 (M−H), was prepared in analogy to example 1, steps A to D. Step C was performed using 2-methoxy-benzenesulfonyl chloride and yielded 4-[3-(2-methoxy-benzenesulfonylamino)-benzoylamino]-benzoic acid ethyl ester, which was hydrolyzed in step D.

Sources & evidence

ORD record
ord-3d41515513e54d81a275fb9cf110d137
Source dataset
uspto-grants-2010_05
Patent number
US07723538B2

Reaction notes

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