2-Fluorobenzenesulphonyl chloride → HCID 68405740, compound

HRID 2241133Notes

Reaction equation

HRID 2241133 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C:12]1[CH:13]=[C:14]([CH:27]=[CH:28][CH:29]=1)[C:15]([NH:17][C:18]1[CH:26]=[CH:25][C:21]([C:22]([OH:24])=[O:23])=[CH:20][CH:19]=1)=[O:16])(=[O:10])=[O:9].F[C:31]1C=CC=C[C:32]=1S(Cl)(=O)=O>>[CH2:31]([O:23][C:22](=[O:24])[C:21]1[CH:25]=[CH:26][C:18]([NH:17][C:15](=[O:16])[C:14]2[CH:27]=[CH:28][CH:29]=[C:12]([NH:11][S:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[F:1])(=[O:9])=[O:10])[CH:13]=2)=[CH:19][CH:20]=1)[CH3:32]

Participants

3

Reactant 2

HCID 1377612-Fluorobenzenesulphonyl chlorideHCID 11979267HCID 11979267, compound

Product 1

HCID 68405740HCID 68405740, compound

Procedure

4-[3-(2-Fluoro-benzenesulfonylamino)-benzoylamino]-benzoic acid, MS (ISP): m/e=413.1 (M−H), was prepared in analogy to example 1, steps A to D. Step C was performed using 2-fluoro-benzensulfonyl chloride and yielded 4-[3-(2-fluoro-benzenesulfonylamino)-benzoylamino]-benzoic acid ethyl ester, which was hydrolyzed in step D.

Sources & evidence

ORD record
ord-3af6718aac0748a69fda297ec646e6c4
Source dataset
uspto-grants-2010_05
Patent number
US07723538B2

Reaction notes

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