3-(Trifluoromethyl)benzenesulfonyl chloride → HCID 68406670, compound

HRID 2241135Notes

Reaction equation

HRID 2241135 reaction equation
[F:1][C:2]([F:32])([F:31])[C:3]1[CH:4]=[C:5]([S:9]([NH:12][C:13]2[CH:14]=[C:15]([CH:28]=[CH:29][CH:30]=2)[C:16]([NH:18][C:19]2[CH:27]=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=2)=[O:17])(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1.F[C:34](F)(F)[C:35]1C=C(S(Cl)(=O)=O)C=CC=1>>[CH2:34]([O:24][C:23](=[O:25])[C:22]1[CH:26]=[CH:27][C:19]([NH:18][C:16](=[O:17])[C:15]2[CH:28]=[CH:29][CH:30]=[C:13]([NH:12][S:9]([C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:31])[F:32])[CH:4]=3)(=[O:10])=[O:11])[CH:14]=2)=[CH:20][CH:21]=1)[CH3:35]

Participants

3

Reactant 2

HCID 27332503-(Trifluoromethyl)benzenesulfonyl chlorideHCID 11977546HCID 11977546, compound

Product 1

HCID 68406670HCID 68406670, compound

Procedure

4-[3-(3-Trifluoromethyl-benzenesulfonylamino)-benzoylamino]-benzoic acid, MS (ISP): m/e=463.3 (M−H), was prepared in analogy to example 1, steps A to D. Step C was performed using 3-trifluoromethyl-benzenesulfonyl chloride and yielded 4-[3-(3-trifluoromethyl-benzenesulfonylamino)-benzoylamino]-benzoic acid ethyl ester, which was hydrolyzed in step D.

Sources & evidence

ORD record
ord-6afe59f3636d456890c319b2643fee5a
Source dataset
uspto-grants-2010_05
Patent number
US07723538B2

Reaction notes

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