3,5-Dichlorobenzenesulfonyl chloride → HCID 68406578, compound

HRID 2241142Notes

Reaction equation

HRID 2241142 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH:12][C:13]2[CH:14]=[C:15]([CH:30]=[CH:31][CH:32]=2)[C:16]([NH:18][C:19]2[CH:27]=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[C:21]([O:28][CH3:29])[CH:20]=2)=[O:17])(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1.Cl[C:34]1C=C(S(Cl)(=O)=O)C=C(Cl)[CH:39]=1>>[CH2:34]([O:24][C:23](=[O:25])[C:22]1[CH:26]=[CH:27][C:19]([NH:18][C:16](=[O:17])[C:15]2[CH:30]=[CH:31][CH:32]=[C:13]([NH:12][S:9]([C:4]3[CH:5]=[C:6]([Cl:8])[CH:7]=[C:2]([Cl:1])[CH:3]=3)(=[O:11])=[O:10])[CH:14]=2)=[CH:20][C:21]=1[O:28][CH3:29])[CH3:39]

Participants

3

Reactant 2

HCID 5223883,5-Dichlorobenzenesulfonyl chlorideHCID 11977660HCID 11977660, compound

Product 1

HCID 68406578HCID 68406578, compound

Procedure

4-[3-(3,5-Dichloro-benzenesulfonylamino)-benzoylamino]-2-methoxy-benzoic acid, MS (ISP): m/e=493.2 (M−H), was prepared in analogy to example 17, steps A to D. Step C was performed using 3,5-dichloro-benzenesulfonyl chloride and yielded 4-[3-(3,5-dichloro-benzenesulfonylamino)-benzoylamino]-2-methoxy-benzoic acid ethyl ester, which was hydrolyzed in step D.

Sources & evidence

ORD record
ord-4b662adeb9124002ac0debd2d4104788
Source dataset
uspto-grants-2010_05
Patent number
US07723538B2

Reaction notes

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