3-Chlorobenzenesulphonyl chloride → HCID 68406665, compound

HRID 2241144Notes

Reaction equation

HRID 2241144 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:8]([NH:11][C:12]2[CH:13]=[C:14]([CH:29]=[CH:30][CH:31]=2)[C:15]([NH:17][C:18]2[CH:26]=[CH:25][C:21]([C:22]([OH:24])=[O:23])=[C:20]([O:27][CH3:28])[CH:19]=2)=[O:16])(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.Cl[C:33]1C=C(S(Cl)(=O)=O)C=C[CH:38]=1>>[CH2:33]([O:23][C:22](=[O:24])[C:21]1[CH:25]=[CH:26][C:18]([NH:17][C:15](=[O:16])[C:14]2[CH:29]=[CH:30][CH:31]=[C:12]([NH:11][S:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)(=[O:9])=[O:10])[CH:13]=2)=[CH:19][C:20]=1[O:27][CH3:28])[CH3:38]

Participants

3

Reactant 2

HCID 179093-Chlorobenzenesulphonyl chlorideHCID 11977662HCID 11977662, compound

Product 1

HCID 68406665HCID 68406665, compound

Procedure

4-[3-(3-Chloro-benzenesulfonylamino)-benzoylamino]-2-methoxy-benzoic acid, MS (ISP): m/e=459.3 (M+H+), was prepared in analogy to example 17, steps A to D. Step C was performed using 3-chloro-benzenesulfonyl chloride and yielded 4-[3-(3-chloro-benzenesulfonylamino)-benzoylamino]-2-methoxy-benzoic acid ethyl ester, which was hydrolyzed in step D.

Sources & evidence

ORD record
ord-a1fa24cbb5f648c98de296b1e6b9e564
Source dataset
uspto-grants-2010_05
Patent number
US07723538B2

Reaction notes

Loading…