3-(Trifluoromethoxy)benzene-1-sulfonyl chloride → HCID 67549724, compound

HRID 2241148Notes

Reaction equation

HRID 2241148 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][C:9]2[CH:17]=[CH:16][C:12]([C:13]([OH:15])=[O:14])=[CH:11][CH:10]=2)=[O:7])=[CH:4][C:3]=1[NH:20][S:21]([C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([O:30][C:31]([F:34])([F:33])[F:32])[CH:25]=1)(=[O:23])=[O:22].FC(F)(F)O[C:38]1C=C(S(Cl)(=O)=O)C=C[CH:43]=1>>[CH2:38]([O:14][C:13](=[O:15])[C:12]1[CH:16]=[CH:17][C:9]([NH:8][C:6](=[O:7])[C:5]2[CH:18]=[CH:19][C:2]([Cl:1])=[C:3]([NH:20][S:21]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([O:30][C:31]([F:32])([F:33])[F:34])[CH:25]=3)(=[O:23])=[O:22])[CH:4]=2)=[CH:10][CH:11]=1)[CH3:43]

Participants

3

Reactant 2

HCID 27772183-(Trifluoromethoxy)benzene-1-sulfonyl chlorideHCID 11977766HCID 11977766, compound

Product 1

HCID 67549724HCID 67549724, compound

Procedure

4-[4-Chloro-3-(3-trifluoromethoxy-benzenesulfonylamino)-benzoylamino]-benzoic acid, MS (ISP): m/e=513.1 (M−H), was prepared in analogy to example 21, steps A to D. Step C was performed using 3-trifluoromethoxy-benzenesulfonyl chloride and yielded 4-[4-chloro-3-(3-trifluoromethoxy-benzenesulfonylamino)-benzoylamino]-benzoic acid ethyl ester, which was hydrolyzed in step D.

Sources & evidence

ORD record
ord-91624842d49c49d29ddbc703e046a308
Source dataset
uspto-grants-2010_05
Patent number
US07723538B2

Reaction notes

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