3-Chlorobenzenesulphonyl chloride → HCID 68406619, compound

Participants

Reaction Steps

4-[3-(3-Chloro-benzenesulfonylamino)-4,5-dimethoxy-benzoylamino]-benzoic acid, MS (ISP): m/e=489.2 (M+H+), was prepared in analogy to example 1, steps A to D. Step A was performed using 3,4-dimethoxy-5-nitro-benzoyl chloride and yielded 4-(3,4-dimethoxy-5-nitro-benzoylamino)-benzoic acid ethyl ester. This was reduced to 4-(3,4-dimethoxy-5-nitro-benzoylamino)-benzoic acid ethyl ester in step B. This was coupled with 3-chloro-benzenesulfonyl chloride in step C, yielding 4-[3-(3-chloro-benzenesulfonylamino)-4,5-dimethoxy-benzoylamino]-benzoic acid ethyl ester, which was hydrolyzed in step D.

Provenance & Evidence