5-Chloro-2-methoxybenzene-1-sulfonyl chloride → HCID 68406303, compound

HRID 2241158Notes

Reaction equation

HRID 2241158 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:34][CH3:35])=[C:6]([S:8]([NH:11][C:12]2[CH:13]=[C:14]([CH:27]=[C:28]([O:32][CH3:33])[C:29]=2[O:30][CH3:31])[C:15]([NH:17][C:18]2[CH:26]=[CH:25][C:21]([C:22]([OH:24])=[O:23])=[CH:20][CH:19]=2)=[O:16])(=[O:10])=[O:9])[CH:7]=1.Cl[C:37]1C=CC(OC)=C(S(Cl)(=O)=O)[CH:42]=1>>[CH2:37]([O:23][C:22](=[O:24])[C:21]1[CH:20]=[CH:19][C:18]([NH:17][C:15](=[O:16])[C:14]2[CH:27]=[C:28]([O:32][CH3:33])[C:29]([O:30][CH3:31])=[C:12]([NH:11][S:8]([C:6]3[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=3[O:34][CH3:35])(=[O:9])=[O:10])[CH:13]=2)=[CH:26][CH:25]=1)[CH3:42]

Participants

3

Reactant 2

HCID 27342725-Chloro-2-methoxybenzene-1-sulfonyl chlorideHCID 11977882HCID 11977882, compound

Product 1

HCID 68406303HCID 68406303, compound

Procedure

4-[3-(5-Chloro-2-methoxy-benzenesulfonylamino)-4,5-dimethoxy-benzoylamino]-benzoic acid, MS (ISP): m/e=519.2 (M−H), was prepared in analogy to example 31, steps A to D. Step C was performed using 5-chloro-2-methoxy-benzenesulfonyl chloride and yielded 4-[3-(5-chloro-2-methoxy-benzenesulfonylamino)-4,5-dimethoxy-benzoylamino]-benzoic acid ethyl ester, which was hydrolyzed in step D

Sources & evidence

ORD record
ord-91919ae8cf5c4edbb857182c38792792
Source dataset
uspto-grants-2010_05
Patent number
US07723538B2

Reaction notes

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