Benzenesulfonyl chloride → HCID 67549619, compound

HRID 2241160Notes

Reaction equation

[C:1]1([S:7]([NH:10][C:11]2[CH:12]=[C:13]([CH:26]=[C:27]([O:31][CH3:32])[C:28]=2[O:29][CH3:30])[C:14]([NH:16][C:17]2[CH:25]=[CH:24][C:20]([C:21]([OH:23])=[O:22])=[CH:19][CH:18]=2)=[O:15])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:33]1(S(Cl)(=O)=O)C=CC=C[CH:34]=1>>[CH2:33]([O:22][C:21](=[O:23])[C:20]1[CH:24]=[CH:25][C:17]([NH:16][C:14](=[O:15])[C:13]2[CH:26]=[C:27]([O:31][CH3:32])[C:28]([O:29][CH3:30])=[C:11]([NH:10][S:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)(=[O:9])=[O:8])[CH:12]=2)=[CH:18][CH:19]=1)[CH3:34]

Participants

Reactant 2

HCID 7369Benzenesulfonyl chloride

HCID 11977990HCID 11977990, compound

Product 1

HCID 67549619HCID 67549619, compound

Procedure

4-[3-(benzenesulfonylamino)-4,5-dimethoxy-benzoylamino]-benzoic acid, MS (ISP): m/e=455.2 (M−H), was prepared in analogy to example 31, steps A to D. Step C was performed using benzenesulfonyl chloride and yielded 4-[3-(benzenesulfonylamino)-4,5-dimethoxy-benzoylamino]-benzoic acid ethyl ester, which was hydrolyzed in step D.

Sources & evidence

ORD record: ord-1187219cb2254be0aaf9159da64a476d
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07723538B2

Reaction notes

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