2,5-Dichlorobenzenesulfonyl chloride → HCID 68405760, compound

HRID 2241161Notes

Reaction equation

HRID 2241161 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[S:9]([NH:12][C:13]1[CH:14]=[C:15]([CH:28]=[C:29]([O:33][CH3:34])[C:30]=1[O:31][CH3:32])[C:16]([NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=1)=[O:17])(=[O:11])=[O:10].Cl[C:36]1C=CC(Cl)=C[C:37]=1S(Cl)(=O)=O>>[CH2:36]([O:24][C:23](=[O:25])[C:22]1[CH:21]=[CH:20][C:19]([NH:18][C:16](=[O:17])[C:15]2[CH:28]=[C:29]([O:33][CH3:34])[C:30]([O:31][CH3:32])=[C:13]([NH:12][S:9]([C:3]3[CH:4]=[C:5]([Cl:8])[CH:6]=[CH:7][C:2]=3[Cl:1])(=[O:11])=[O:10])[CH:14]=2)=[CH:27][CH:26]=1)[CH3:37]

Participants

3

Reactant 2

HCID 794012,5-Dichlorobenzenesulfonyl chlorideHCID 11977991HCID 11977991, compound

Product 1

HCID 68405760HCID 68405760, compound

Procedure

4-[3-(2,5-Dichloro-benzenesulfonylamino)-4,5-dimethoxy-benzoylamino]-benzoic acid, MS (ISP): m/e=523.1 (M−H), was prepared in analogy to example 31, steps A to D. Step C was performed using 2,5-dichloro-benzenesulfonyl chloride and yielded 4-[3-(2,5-dichloro-benzenesulfonylamino)-4,5-dimethoxy-benzoylamino]-benzoic acid ethyl ester, which was hydrolyzed in step D.

Sources & evidence

ORD record
ord-4f587feda3aa4159b0dc7c04f35ef868
Source dataset
uspto-grants-2010_05
Patent number
US07723538B2

Reaction notes

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