Ethanol → Ethyl 2-fluoro-4-nitrobenzoate

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Reaction Steps

A solution of 2-fluoro-4-nitro-benzoic acid (1.0 g, 5.0 mmol) in ethanol (10.0 ml) was treated with concentrated sulfuric acid (0.30 ml) and stirred at reflux overnight. On cooling to room temperature and then to 0° C. a crystalline precipitate formed. This was filtered washing with ethanol/water 2:1, and dried under vacuum, yielding 2-fluoro-4-nitro-benzoic acid ethyl ester (0.75 g, 65%) as an off-white crystalline solid.

Provenance & Evidence