3-(4-chlorobenzyl)-5-(4-(benzyloxy)-3-fluorophenyl)pyrimidin-4(3H)-one → 3-(4-chlorobenzyl)-5-(3-fluoro-4-hydroxyphenyl)pyrimidin-4(3H)-one

HRID 2241221Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2241221
[Cl:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][N:7]2[C:12](=[O:13])[C:11]([C:14]3[CH:19]=[CH:18][C:17]([O:20]CC4C=CC=CC=4)=[C:16]([F:28])[CH:15]=3)=[CH:10][N:9]=[CH:8]2)=[CH:4][CH:3]=1>FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[C:12](=[O:13])[C:11]([C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[C:16]([F:28])[CH:15]=3)=[CH:10][N:9]=[CH:8]2)=[CH:29][CH:30]=1

Komponenten

3

Edukt 1

HCID 685138743-(4-chlorobenzyl)-5-(4-(benzyloxy)-3-fluorophenyl)pyrimidin-4(3H)-one

Produkt 1

HCID 685164823-(4-chlorobenzyl)-5-(3-fluoro-4-hydroxyphenyl)pyrimidin-4(3H)-oneAusbeute 75,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

In a small round bottom flask, a solution of 3-(4-chlorobenzyl)-5-(4-(benzyloxy)-3-fluorophenyl)pyrimidin-4(3H)-one (0.17 g, 0.40 mmol) was heated in trifluoroacetic acid (5 mL) for 4 hours. The solvent was evaporated and the residue was dried under vacuum to afford the title compound as a white colored solid (0.1 g, 75%). LRMS (APCI pos) m/e 331.0 (M+1).

Aufarbeitung

  1. customThe solvent was evaporated
  2. customthe residue was dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-f05d59fd3594438a994a03b23c22f446
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07723330B2

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