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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2241525Generated: November 3, 2026

Diisopropylethylamine → HCID 68683112, compound

https://huagongshe.com/reaction/2241525

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiisopropylethylamineHCID 81531—
ReactantO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
Reactant4,4-DifluoropiperidineHCID 2758352—
ReactantHCID 68681046HCID 68681046—
SolventDimethylformamideHCID 6228—
ProductHCID 68683112HCID 6868311274%

Reaction Steps

The title compound was synthesized in analogy to example 1, from 5-((R)-2-pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-1H-indole-2-carboxylic acid hydrochloride, O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (commercially available), 4,4-difluoropiperidine (commercially available) and N,N-diisopropylethylamine in N,N-dimethylformamide, to give the desired product as a colorless solid (74%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07723325B2
Source datasetuspto-grants-2010_05
ORD IDord-86157a191c5b4515a1fd01e218754453
Source noteuspto-grants-2010_05