HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Cyclopentylpiperazine → [5-(4-Cyclopentyl-piperazine-1-carbonyl)-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-morpholin-4-yl-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Cyclopentylpiperazine | HCID 806421 | — |
| Reactant | 2-(Morpholine-4-carbonyl)-1-(2,2,2-trifluoro-ethyl)-1H-indole-5-carboxylic acid | HCID 68681581 | — |
| Product | [5-(4-Cyclopentyl-piperazine-1-carbonyl)-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-morpholin-4-yl-methanone | HCID 24756898 | 49% |
Reaction Steps
The title compound was synthesized in analogy to example 46, intermediate e), from 2-(morpholine-4-carbonyl)-1-(2,2,2-trifluoro-ethyl)-1H-indole-5-carboxylic acid and 1-cyclopentylpiperazine (commercially available), to give the desired product as a white solid (49%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723325B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-92225413ca504d3888c2e6afe8a6777e |
| Source note | uspto-grants-2010_05 |