HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 68683216, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | [5-(4-Cyclopentyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4,4-difluoro-piperidin-1-yl)-methanone | HCID 68681312 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68683216 | HCID 68683216 | 35% |
Reaction Steps
The title compound was synthesized in analogy to example 51, from [5-(4-cyclopentyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4,4-difluoro-piperidin-1-yl)-methanone (example 8), sodium hydride and methanesulfonyl chloride in N,N-dimethylformamide, to give the desired product as a colorless foam (35%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723325B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-01ce60ce3fed425ab52babac18d7b994 |
| Source note | uspto-grants-2010_05 |