HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 4-[2-(4,4-Difluoro-piperidine-1-carbonyl)-5-(4-isopropyl-piperazine-1-carbonyl)-indol-1-yl]-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 4-Methoxycarbonylphenylboronic acid | HCID 2734369 | — |
| Reactant | (4,4-Difluoro-piperidin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone | HCID 68680853 | — |
| Catalyst | Cupric acetate | HCID 8895 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-[2-(4,4-Difluoro-piperidine-1-carbonyl)-5-(4-isopropyl-piperazine-1-carbonyl)-indol-1-yl]-benzoic acid methyl ester | HCID 68680508 | 40% |
Reaction Steps
The title compound was synthesized in analogy to example 66, from (4,4-difluoro-piperidin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone (example 32), 4-methoxycarbonylphenylboronic acid, copper(II) acetate and pyridine in dichloromethane, to give the desired product as a colorless foam (40%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723325B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-c902f14b7a4740e3aa3f0a790c6d10f8 |
| Source note | uspto-grants-2010_05 |