HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → [5-(4-Cyclopentyl-piperazine-1-carbonyl)-1-p-tolyl-1H-indol-2-yl]-(1,1-dioxo-thiomorpholin-4-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Tolylboronic acid | HCID 79799 | — |
| Reactant | [5-(4-Cyclopentyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(1,1-dioxo-thiomorpholin-4-yl)-methanone | HCID 68680722 | — |
| Catalyst | Cupric acetate | HCID 8895 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | [5-(4-Cyclopentyl-piperazine-1-carbonyl)-1-p-tolyl-1H-indol-2-yl]-(1,1-dioxo-thiomorpholin-4-yl)-methanone | HCID 68681238 | 69% |
Reaction Steps
The title compound was synthesized in analogy to example 66, from [5-(4-cyclopentyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(1,1-dioxo-thiomorpholin-4-yl)-methanone (example 34), 4-methylphenylboronic acid, copper(II) acetate and pyridine in dichloromethane, to give the desired product as a light yellow solid (69%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723325B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-5964d513523640d58241508efb40278a |
| Source note | uspto-grants-2010_05 |