反应详情

3.8 g (25 mmol) of methyl 5-amino-pyridine-2-carboxylate were dissolved in 75 ml of anhydrous pyridine, and 5.8 g (30 mmol) of 4-fluorobenzenesulfonyl chloride were added in portions, whereupon the temperature of the reaction solution rose to 35° C. After 1 hour, the mixture was concentrated in vacuo and the residue was triturated with water, filtered off with suction, washed with water and dried. This gave 7.3 g of product, melting point 183° to 185° C.

1. customrose to 35° C
2. concentrationthe mixture was concentrated in vacuo
3. customthe residue was triturated with water
4. filtrationfiltered off with suction
5. washwashed with water
6. customdried