HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 68681221, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Bromomethylcyclopropane | HCID 81503 | — |
| Reactant | HCID 68680808 | HCID 68680808 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68681221 | HCID 68681221 | 53% |
Reaction Steps
The title compound was synthesized in analogy to example 51, from (RS)-(4,4-difluoro-piperidin-1-yl)-[5-(3-dimethylamino-pyrrolidine-1-carbonyl)-1H-indol-2-yl]-methanone (example 42, intermediate a)), sodium hydride and cyclopropylmethyl bromide in N,N-dimethylformamide, to give the desired product as a colorless foam (53%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723325B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-3dc01501128e4df1b9a891d3fbdcb0fa |
| Source note | uspto-grants-2010_05 |