HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2241626Generated: November 3, 2026
Pyridine → [1-Cyclopropyl-5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4,4-difluoro-piperidin-1-yl)-methanone
https://huagongshe.com/reaction/2241626
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Cyclopropylboronic acid | HCID 2760897 | — |
| Reactant | (4,4-Difluoro-piperidin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone | HCID 68680853 | — |
| Catalyst | Cupric acetate | HCID 8895 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | [1-Cyclopropyl-5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4,4-difluoro-piperidin-1-yl)-methanone | HCID 68682294 | 12% |
Reaction Steps
The title compound was synthesized in analogy to example 66, from (4,4-difluoro-piperidin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone (example 32), cyclopropylboronic acid (commercially available), copper(II) acetate and pyridine using chloroform as solvent and stirring at 50° C. for 4 days, to give the desired product as a light brown foam (12%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07723325B2 |
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| Source dataset | uspto-grants-2010_05 |
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| ORD ID | ord-81a97690b0124166a31e608b9b95b427 |
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| Source note | uspto-grants-2010_05 |
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