Pyridine → HCID 68681496, compound

HRID 2241633Notes

Reaction equation

HRID 2241633 reaction equation
[CH:1]1([N:5]2[CH2:10][CH2:9][N:8]([C:11]([C:13]3[CH:14]=[C:15]4[C:19](=[CH:20][CH:21]=3)[NH:18][C:17]([C:22]([N:24]3[CH2:29][CH2:28][C:27]([F:31])([F:30])[CH2:26][CH2:25]3)=[O:23])=[CH:16]4)=[O:12])[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[CH2:32]1[O:40][C:39]2[CH:38]=[CH:37][C:36](B(O)O)=[CH:35][C:34]=2[O:33]1.N1C=CC=CC=1>ClCCl.C([O-])(=O)C.[Cu+2].C([O-])(=O)C>[O:33]1[C:34]2[CH:35]=[CH:36][C:37]([N:18]3[C:19]4[C:15](=[CH:14][C:13]([C:11]([N:8]5[CH2:7][CH2:6][N:5]([CH:1]6[CH2:2][CH2:3][CH2:4]6)[CH2:10][CH2:9]5)=[O:12])=[CH:21][CH:20]=4)[CH:16]=[C:17]3[C:22]([N:24]3[CH2:25][CH2:26][C:27]([F:30])([F:31])[CH2:28][CH2:29]3)=[O:23])=[CH:38][C:39]=2[O:40][CH2:32]1

Participants

6

Reactant 3

HCID 1049PyridineHCID 2734371(2H-1,3-benzodioxol-5-yl)boronic acidHCID 68683577[5-(4-Cyclobutyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4,4-difluoro-piperidin-1-yl)-methanone

Product 1

HCID 68681496HCID 68681496, compoundYield 24%

Reagents, catalysts & solvents 2

HCID 8895Cupric acetateCatalystHCID 6344DichloromethaneSolvent

Procedure

The title compound was synthesized in analogy to example 66, from [5-(4-cyclobutyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4,4-difluoro-piperidin-1-yl)-methanone (example 41), 3,4-methylenedioxybenzeneboronic acid, copper(II) acetate and pyridine in dichloromethane, to give the desired product as a colorless foam (24%).

Sources & evidence

ORD record
ord-7bd5b0cbb17c4773b97a703759dda9e9
Source dataset
uspto-grants-2010_05
Patent number
US07723325B2

Reaction notes

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