HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4'-Bipiperidine → HCID 68682122, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4'-Bipiperidine | HCID 78607 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 2-(Ethoxycarbonyl)-1H-indole-5-carboxylic acid | HCID 18071365 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68682122 | HCID 68682122 | 67% |
Reaction Steps
The title compound was synthesized in analogy to example 1, intermediate a), from 1H-indole-2,5-dicarboxylic acid 2-ethyl ester, O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (commercially available), 4-piperidinopiperidine (commercially available) and N,N-diisopropylethylamine in N,N-dimethylformamide, to give the desired product as a brown solid (67%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723325B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-b26e9dfc41354c40a67600c4660b6226 |
| Source note | uspto-grants-2010_05 |