HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 68683154, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2,2,2-Trifluoroethyl Methanesulfonate | HCID 556565 | — |
| Reactant | HCID 68683127 | HCID 68683127 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68683154 | HCID 68683154 | 73% |
Reaction Steps
The title compound was synthesized in analogy to example 51, from [5-(4-cyclobutyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(1,1-dioxothiomorpholin-4-yl)-methanone (example 202), sodium hydride and 2,2,2-trifluoroethyl methanesulfonate in N,N-dimethylformamide, to give the desired product as a yellow solid (73%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723325B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-b983942087484853ae8e0c47ff11ab61 |
| Source note | uspto-grants-2010_05 |