HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 68681597, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 3-Fluorophenylboronic acid | HCID 2733986 | — |
| Reactant | [2-(1,1-Dioxo-thiomorpholine-4-carbonyl)-1H-indol-5-yl]-(4-isopropyl-piperazin-1-yl)-methanone | HCID 68681206 | — |
| Catalyst | Cupric acetate | HCID 8895 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 68681597 | HCID 68681597 | 35% |
Reaction Steps
The title compound was synthesized in analogy to example 66, from [2-(1,1-dioxo-thiomorpholine-4-carbonyl)-1H-indol-5-yl]-(4-isopropyl-piperazin-1-yl)-methanone (example 1), 3-fluorophenylboronic acid, copper(II) acetate, pyridine and using chloroforme instead of dichloromethane as solvent, to give the desired product as a colorless foam (35%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723325B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-b227e5a67c304fa8bf72ed4aa94f91b8 |
| Source note | uspto-grants-2010_05 |